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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2011  |  Volume : 15  |  Issue : 2  |  Page : 127-132
Oral lichen planus: An update on pathogenesis and treatment


Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India

Correspondence Address:
N Lavanya
Senior Lecturer, Department of Oral and Maxillofacial Pathology, Ragas Dental College, 2/102, East Coast Road, Uthandi, Chennai - 600 119
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.84474

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Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucus membrane of the oral cavity. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. Several antigen-specific and nonspecific inflammatory mechanisms have been put forward to explain the accumulation and homing of CD8+ T cells subepithelially and the subsequent keratinocyte apoptosis. A wide spectrum of treatment modalities is available, from topical corticosteroids to laser ablation of the lesion. In this review, we discuss the various concepts in the pathogenesis and current treatment modalities of OLP.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007