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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL RESEARCH Table of Contents   
Year : 2003  |  Volume : 7  |  Issue : 2  |  Page : 40-43
Monoclonal antibody to desmosomal antigen Dsg1: A reliable adjunct to histopathology

1 Senior lecturer in Oral Pathology, SGRD Inst. of Dental Sciences, Amritsar, India
2 Department of Oral Pathology, KLES Inst. of Dental Sciences and Research, Belgaum, India

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Simarpreet Virk
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Desmosomes are cell surface modifications that provide strong adhesion between epithelial cells. The presence of desmosomes in a majority of epithelia make them useful epithelial markers. This paper describes a monoclonal antibody 32-2B to desmosomal glycoprotein 1 (Dsg1) or desmoglein, preserved in routinely processed paraffin embedded sections. This antibody was tested for its ability to stain normal oral epithelium and epithelium derived tumors. It reacted with all oral epithelial specimens tested but showed negative staining in those specimens which lacked desmosomal structures like connective tissue cells and lymph nodes. These characteristics demonstrate that 32-2B is a reliable epithelial marker that may be useful in diagnostic histopathology.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007