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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL RESEARCH Table of Contents   
Year : 2003  |  Volume : 7  |  Issue : 2  |  Page : 44-45
Estimation of serum antioxidant enzymes superoxide dismutase and glutathione peroxidase in oral submucous fibrosis: A biochemical study

1 Department of Oral and Maxillo Facial Pathology and Microbiology, GDCH, Nagpur, India
2 Professor of Biochemistry, Government Medical College and Hospital, Mumbai, India

Correspondence Address:
V K Hazarey
Department of OMFPM, GDCH, Nagpur 63
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Source of Support: None, Conflict of Interest: None

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The aim of the present study was to estimate the serum status of antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GPX) in oral submucous fibrosis (OSF) which is a precancerous condition common in Indian subcontinent. A total of sixty subjects were included in the study comprising of 30 cases of oral submucous fibrosis and 30 healthy controls. The haemolysate levels of antioxidant enzymes (SOD and GPX) were estimated using Ciba corning express plus autoanalyzer for spectrometry. In OSF, serum antioxidant enzyme levels were found to be decreased (mean SOD 86.6320.36 and mean GPX 1.500.30 U/ml) compared to the control group (mean SOD 127.118.14 and mean GPX 2.710.43 U/ml). The results suggest that low values of SOD and GPX may be associated with the development of carcinoma in oral submucous fibrosis.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007