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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL RESEARCH Table of Contents   
Year : 2007  |  Volume : 11  |  Issue : 1  |  Page : 23-27
An estimation of serum malondialdehyde, superoxide dismutase and vitamin A in oral submucous fibrosis and its clinicopathologic correlation

1 Department of Oral Pathology and Microbiology, Tatyasaheb Kore Dental College and Research Center, New Pargaon - 416 137, India
2 Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Aurangabad - 431 001, Maharashatra, India

Correspondence Address:
J V Tupkari
Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Ghati, Aurangabad - 431 001, Maharashatra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.33960

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Recently, there has been growing interest in studies that concern with reactive oxygen species in various diseases. Several studies have shown the role of oxidant-antioxidants system in the causation and progression of various types of cancer including oral cancer. However, considering its high prevalence in India and the potential to undergo malignant transformation oral submucous fibrosis (OSF) has not been widely investigated with respect to lipid peroxidation and antioxidants. This definitely has developed a responsibility over the oral pathologists to find out the exact role of lipid peroxidation and antioxidants in OSF. With this view in mind, the present study was undertaken and an attempt was made to correlate the serum levels of lipid peroxidation product malondialdehyde (MDA), antioxidants superoxide dismutase (SOD) and vitamin A in relation to clinical and histopathological grading of OSF. The progressively increased MDA and progressively decreased SOD and vitamin A levels has positive correlation with clinical grades of OSF.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007