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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL RESEARCH Table of Contents   
Year : 2007  |  Volume : 11  |  Issue : 2  |  Page : 48-50
Quantification of plasma fibrinogen degradation products in oral submucous fibrosis: A clinicopathologic study

1 Department of Oral Pathology, Modern Dental College and Research Centre, Bijasan Road, Gandhinagar, Indore (MP) - 453 112, India
2 Department of Oral Pathology, Government Dental College and Hospital, Ghate Hospital Campus, Aurangabad (Maharashtra), India

Correspondence Address:
Suresh Barpande
Department of Oral Pathology, Government Dental College and Hospital, Ghate Hospital Campus, Aurangabad (Maharashtra)
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.37379

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Oral submucous fibrosis (OSMF) has a multifactorial etiology. Recent investigations have shown the role of fibrinogen degradation products (FDP) in the causation of OSMF. A study of 35 cases showed a significant linear increase of plasma FDP levels with an increase in the clinical grade. Comparison with the histological grade of OSMF showed an increase in plasma FDP levels with increase in histological grade of OSMF, but was not statistically significant. Plasma FDP is reported to be an early indicator of fibrin deposition. When the plasma FDP increases, the fibrin deposited also increases. This strengthens the finding that OSMF is primarily a change of connective tissue causing excessive deposition of fibrin. This in turn leads to restriction of mouth opening.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007