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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2011  |  Volume : 15  |  Issue : 3  |  Page : 278-282
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients

1 Department of Oral Pathology and Microbiology, Thai Moogambigai Dental College and Hospital, Chennai, India
2 Department of Oral Pathology and Microbiology, Vishnu Dental College, Bhimavaram, India
3 Department of Oral Pathology and Microbiology, Ragas Dental College and Hospital, Chennai, India

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.86680

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Sister chromatid exchange (SCE) test is a sensitive, biomarker of genotoxic substances. The frequency of SCE in lymphocytes of ten pan chewing patients, oral submucous fibrosis (OSF) patients and age matched healthy controls were investigated. The frequency of mean SCE/cell was found to be 10.428 ± 0.755 in OSF patients, 8.752 ± 0.383 in case of pan chewers as compared to 5.912 ± 0.310 in controls. These values show a significant increase in frequency of SCE/cell in OSF patients and pan chewers when compared with that of healthy controls. There is a positive correlation co-efficient of SCE/cell with frequency, quantity, duration, intensity and period of exposure of pan-parag to oral mucosa in pan chewers and OSF patients indicating genotoxic effect of pan. Thus SCE could be used as a biomarker in chewers also to assess the level of genomic damage and to advocate efficient control measures.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007