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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

CASE REPORT Table of Contents   
Year : 2011  |  Volume : 15  |  Issue : 3  |  Page : 311-315
Symmetric palatal swelling as the first clinical manifestation of a mantle cell non-Hodgkin's lymphoma: A case report and review of literature

1 Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Martin-Luther-University, Halle-Wittenberg (S.), Germany
2 Institute of Pathology, Martin-Luther-University, Halle-Wittenberg (S.), Germany
3 Department of Neurosurgery, Martin Luther University, Halle Wittenberg (S.), Germany

Correspondence Address:
Konstanze Scheller
Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Martin Luther University, Halle Wittenberg, Ernst Grube Strasse 40, 06120 Halle (S.)
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.86703

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The mantle cell lymphoma (MCL) is a rare (3.7%) low-grade non-Hodgkin lymphoma originating from the B-cell precursor-subpopulation. The clinical appearance in the oral cavity is rare. Since 1980, nine cases have been reported. A 41-year-old patient showed a MCL presenting with a symmetric, painless palatal swelling without any other clinical symptoms. Histological sections revealed malignant monotonous lymphoid cells (CD20+, CD43+, Ki67+) and the typical cyclinD1 over-expression by the chromosomal translocation t(11;14)(q13;q32). The proliferating cells weekly expressed CD5, kappa-and lambda-light chains and no EMA, CD10, bcl-6, CD30, and CD23. The patient was treated according to the European MCL younger study, and the MCL is regressive. The high incidence of dento-alveolar abscesses, inflammations, or benign tumor-formations leads to associate any maxillary or palatal swelling with this clinical condition. Considering the serious consequences of a missed therapy a histological examination of any untypical "swelling" is demanded.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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