|
 |
|
BRIEF REVIEW |
|
|
|
|
| Year : 2014 | Volume
: 18
| Issue : 4 | Page : 117-120 |
| |
Update on the classification of hemangioma
Antony George, Varghese Mani, Ahammed Noufal
Department of Oral and Maxillofacial Pathology, MES Dental College, Perinthalmanna, Kerala, India
| Date of Submission | 28-Feb-2012 |
| Date of Acceptance | 06-Jun-2014 |
| Date of Web Publication | 20-Sep-2014 |
Correspondence Address:
Antony George
Department of Oral and Maxillofacial Pathology, MES Dental College, Perinthalmanna, Malappuran - 679 338, Kerala
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-029X.141321
 Abstract | | |
Despite the fact that a biological classification of congenital vascular tumors and malformations was first published in 1982 by Mulliken and Glowacki, significant confusion still prevails due to the indiscriminate and interchangeable use of the terms hemangioma and vascular malformation. Hemangiomas are true neoplasms of endothelial cells and should be differentiated from vascular malformations which are localized defects of vascular morphogenesis. On an analysis of various scientific articles and latest edition of medical text books an inappropriate use of various terms for vascular lesions was found, contributing further towards the confusion. The widely accepted International Society for the Study of Vascular Anomalies (ISSVA) classification differentiates lesions with proliferative endothelium from lesions with structural anomalies and has been very helpful in standardizing the terminologies. In addition to overcoming obstacles in communication when describing a vascular lesion, it is important that we adhere to the correct terminology, as the therapeutic guidelines, management and follow-up of these lesions differ.
Keywords: Classification, congenital hemangioma, hemangioma, infantile hemangioma, international society for the study of vascular anomalies, vascular malformation
How to cite this article:
George A, Mani V, Noufal A. Update on the classification of hemangioma
. J Oral Maxillofac Pathol 2014;18, Suppl S1:117-20 |
| Introduction | |  |
The classification and the terminologies used for various vascular lesions have been very confusing despite the fact that a biological classification was first published in 1982 by Mulliken and Glowacki. [1] This classification was later adopted by the International Society for the Study of Vascular Anomalies (ISSVA) in their first workshop held in Rome during June 1996. [2] This continuing workshop now takes place every 2 years in various countries around the world. The ISSVA is an organization comprising of specialists in various disciplines interested in vascular anomalies and was founded in 1992 in Budapest with the aim of achieving consensus among health care professionals on the terminology, to further the knowledge of pathogenesis, diagnosis and treatment of these vascular lesions. [3] An analysis of various scientific articles and latest edition of text books showed that significant confusion still prevails due to the indiscriminate, inappropriate and interchangeable use of various terms. [3]
Classification
Historically benign vascular tumors were classified: (1) According to the type of fluid they contained as hemangioma (blood-containing lesion) and lymphangioma (lymph-containing lesion) and (2) according to the size of the vascular channels as capillary (small diameter vascular channels) and cavernous (large diameter vascular channels). [4] Mulliken and Glowacki described a biological classification based on endothelial cell characteristics, physical findings and natural history, that differentiates vascular lesions with endothelial cell proliferation (example hemangioma) from lesions with structural anomalies (vascular malformations). [1],[2],[3],[4],[5] The ISSVA modified it in their continuing workshops, differentiating vascular tumors from vascular malformations based on their clinical appearance, radiological features, pathological features and biological behaviour [Table 1]. [2],[3],[5] | Table 1: Modified International Society for the Study of Vascular Anomalies (ISSVA) classification
Click here to view |
| Discussion | | |
Hemangiomas grow by endothelial cell hyperplasia and should be differentiated from vascular malformations, which are not true neoplasms but are localized defects of vascular morphogenesis caused by dysfunction in embryogenesis and vasculogenesis [Table 2]. [2],[3],[4],[5],[6],[7],[8],[9],[10] The Greek suffix ''oma'' means cellular proliferation of a tumor and thus the term hemangioma is erroneous when used for malformations. [2] Hemangiomas are the most common benign soft tissue tumor of infancy and childhood, occurring in 12% of all infants and are found in greater frequency in girls, whites, premature infants, twins and are usually born to mothers of higher maternal age. [2],[3],[4],[5],[6],[7],[8] They occur most frequently in head and neck region (60%), followed by the trunk (25%) and the extremities (15%), which are grouped into Infantile Hemangiomas (IHs) and Congenital Hemangiomas (CHs). [2],[3],[8] | Table 2: Differences between infantile hemangioma and vascular malformations
Click here to view |
IHs (outdated term juvenile hemangioma) arises during the first 8 weeks of life as an area of discoloration or telangiectasia. The lesion exhibits a rapid proliferative phase during early childhood for 6-12 months and grows into a raised rubbery bright-red tumor (resembling a strawberry, hence outdated term strawberry hemangioma). [4],[5],[7],[8] This is followed by gradual involution and a spontaneous regression by the age of 5-9 years. 50% of all hemangiomas will completely involute by the age of 5 years and 90% by the age of 9 years. [4],[5],[7],[8] 40% of involuted lesions may either show scaring, wrinkling, telangiectasia, or loose fibro-fatty tissue. [5],[6],[8] IHs can be grouped into focal, segmental and indeterminate, or depending on the depth of the lesion from the skin surface as superficial, deep and mixed. Focal IHs are the most common variant, appearing as localized raised tumor-like lesion that tends to occur at the area of embryological fusion. Segmental IHs are flat plaque-like larger lesions that show a geographic segmental distribution and Indeterminate IHs shows characteristics of both focal and segmental IHs. [5] Color varies with the depth of the lesion; they can be bright red (superficial), purple, blue, or normal skin colour (deep). [3],[4],[5]
CHs are clinically present as fully developed lesions at birth and either rapidly involutes during the first year of life or may never show involution. These lesions do not exhibit a proliferative phase and do not grow after birth. [5],[6] Rapidly Involuting Congenital Hemangiomas (RICH) are present at birth, either as red-purple color plaques with coarse telangiectasia, or as flat violaceous lesions, or as a raised greyish tumor surrounded by a pale halo with multiple tiny telangiectasia. RICH undergo a rapid regression phase and completely disappear by 12-18 months of age. [5],[6] Non Involuting Congenital Hemangiomas (NICH) are also present at birth, appearing as pink or purple colored plaque-like lesions with prominent overlying coarse telangiectasia and peripheral blanching. NICH do not show a regression phase and grows proportionately with the growth of the child. [5],[6] Main differences between congenital and infantile hemangiomas are summarised in [Table 3]. [2],[4],[5],[6],[7],[10]
Apart from hemangiomas of soft tissue, scientific literatures have reported central hemangiomas (hemangioma of bone) and intramuscular hemangiomas. Many researchers in addition to the World Health Organization (WHO) believe that most if not all such proposed lesions are vascular malformations rather than true neoplasms. [9] ISSVA classification has not been applied for the categorization of these osseous vascular lesions. [9]
| Conclusion | | |
Therapeutic guidelines, management and follow-up of hemangiomas and vascular malformations differ and are beyond the scope of this article. A good classification is important for categorising information, recording data, proper communication, guiding treatment plans, obtaining prognostic information and should be easy to understand and applied by the clinicians. It is our duty to be consistent in our terminology and classification of vascular lesions in all our scientific writings and presentations in order to communicate effectively, understand its pathophysiology, promote research and develop newer therapeutics. Terms to be avoided when describing these lesions include angioma, birthmarks, capillary hemangioma, cavernous hemangioma, juvenile hemangioma, strawberry hemangioma and inappropriate interchangeable use of the terms hemangioma and vascular malformation.
| Acknowledgement | | |
Manoj Vengal, Professor of Oral Medicine and C. S. Jayapalan, Professor of Oral Pathology, for their critical evaluation and valuable guidance in manuscript preparation and general support.
| References | | |
| 1. | Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: A classification based on endothelial characteristics. Plast Reconstr Surg 1982;69:412-22. 
[PUBMED] |
| 2. | Enjolras O, Wassef M, Chapot R. Color Atlas of Vascular Tumors and Vascular Malformations. 1 st ed., New York: Cambridge University Press; 2007.
|
| 3. | Redondo P. Vascular Malformations [I] Concept, Classification, Pathogenesis and Clinical Features. Actas Dermosifiliogr 2007;98:141-58.
[PUBMED] |
| 4. | Donnelly LF, Adams DM, Bisset GS. Vascular malformations and hemangiomas: A practical approach in a multidisciplinary clinic. Am J Roentgenol 2000;174:597-608.
|
| 5. | Restrepo R, Palani R, Cervantes L, Duarte A, Amjad I, Altman N. Hemangiomas revisited: The useful, the unusual and the new. Pediatr Radiol 2011;41:895-915.
|
| 6. | Eivazi B, Ardelean M, Baumler M, Berlien H, Cremer H, Elluru R, et al. Update on hemangiomas and vascular malformations of the head and neck. Eur Arch Otorhinolaryngol 2009;266:187-97.
|
| 7. | Dadras SS, North PE, Bertoncini J, Mihm MC, Detmar M. Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol 2004;17:1068-79.
|
| 8. | Murthy J. Vascular anomalies. Indian J Plast Surg 2005;38:56-62.
 |
| 9. | Bruder E, Perez-Atayde AR, Jundt G, Alomari AI, Rischewski J, Fishman SJ, et al. Vascular lesions of bone in children, adolescents, and young adults. A clinicopathologic reappraisal and application of the ISSVA classification. Virchows Arch 2009;454:161-79.
|
| 10. | George A, Jayapalan CS, Noufal A. Diagnosing hemangioma and vascular malformations of head and neck. Health Sciences 2014;3:JS002C.
|
[Table 1], [Table 2], [Table 3]
| This article has been cited by | | 1 |
Prenatal diagnosis and management of a giant intrahepatic arteriovenous malformation—Sonographic findings, clinical implications, and treatment |
|
| Adeline Walter, Elina Calite, Andreas Müller, Jörg C. Kalff, Carsten Meyer, Annegret Geipel, Ulrich Gembruch, Christine Schreiner | | Clinical Case Reports. 2022; 10(8) | | [Pubmed] | [DOI] | | | 2 |
Spontaneous evolution patterns of focal congenital hepatic hemangiomas: a case series of 25 patients |
|
| Caroline Rutten, Delphine Ladarre, Oanez Ackermann, Emmanuel Gonzales, Catherine Guettier, Stéphanie Franchi-Abella | | Pediatric Radiology. 2022; | | [Pubmed] | [DOI] | | | 3 |
Hemangioma in the lower labial vestibule of an eleven-year-old girl: A case report |
|
| Ashwag Yagoub Aloyouny, Afrah Jaber Alfaifi, Shahad Mohammed Aladhyani, Ahad Ali Alshalan, Hadeel Mohammed Alfayadh, Hend Mahmoud Salem | | World Journal of Clinical Cases. 2022; 10(5): 1617 | | [Pubmed] | [DOI] | | | 4 |
Incidental finding of intra-abdominal hemangioma in an infant presenting with intestinal obstruction: a case report |
|
| Parveen Kumar, Arti Khatri, Somshankar Chowdhury, Nidhi Mahajan, Geetika Mathur | | World Journal of Pediatric Surgery. 2022; 5(1): e000335 | | [Pubmed] | [DOI] | | | 5 |
Cavernous hemangioma resembling lymphangioma circumscriptum: The central role of dermoscope in diagnosis |
|
| Khairuddin Djawad | | Journal of Dermatology and Dermatologic Surgery. 2022; 26(1): 54 | | [Pubmed] | [DOI] | | | 6 |
A Case Report of Multiple Capillary Hemangioma in a Chronic Myeloid Leukemia Patient Taking Tyrosine Kinase Inhibitors |
|
| Hyun Jeong Byun, Donghwi Jang, Jongeun Lee, Se Jin Oh, Youngkyoung Lim, Ji-Hye Park, Jong Hee Lee, Dong-Youn Lee | | Annals of Dermatology. 2021; 33(3): 278 | | [Pubmed] | [DOI] | | | 7 |
Unusual presentation of oral hemangioma in tongue and the potential use of propolis as an adjunctive treatment |
|
| Susan Susan, Munir Ravalia, Felix Zulhendri | | Clinical Case Reports. 2021; 9(12) | | [Pubmed] | [DOI] | | | 8 |
Reappraising Schwannoma-Hemangioma Composite Tumors as Synchronous Tumorigenic Entities With Conjoined Histomorphology: A Case Report |
|
| Subramaniam Ramkumar | | Cureus. 2021; | | [Pubmed] | [DOI] | | | 9 |
Update on infantile hemangioma |
|
| Hye Lim Jung | | Clinical and Experimental Pediatrics. 2021; 64(11): 559 | | [Pubmed] | [DOI] | | | 10 |
Successful anesthetic management of a giant lower lip hemangioma patient using high flow nasal cannula
-a case report- |
|
| Ji Yeon Kim, Hangaram Kim, Min Hee Heo, Kyung Woo Kim, Sang-Il Lee, Kyung-Tae Kim, Jang Su Park, Won Joo Choe, Jun Hyun Kim | | Korean Journal of Anesthesiology. 2021; 74(6): 546 | | [Pubmed] | [DOI] | | | 11 |
Field emission scanning electron microscopy study of orbital venous malformation |
|
| Dipankar Das, Kasturi Bhattacharjee, Surjendu Maity, Saurabh Deshmukh, Riddhi Raichura, Mohit Garg, Apurba Deka | | Indian Journal of Ophthalmology - Case Reports. 2021; 1(4): 848 | | [Pubmed] | [DOI] | | | 12 |
Propranolol in the Treatment of Infantile Hemangiomas |
|
| Xin Tan, Shu Guo, Chenchao Wang | | Clinical, Cosmetic and Investigational Dermatology. 2021; Volume 14: 1155 | | [Pubmed] | [DOI] | | | 13 |
Infantile Hemangioma: An Updated Review |
|
| Alexander K.C. Leung, Joseph M. Lam, Kin F. Leong, Kam L. Hon | | Current Pediatric Reviews. 2021; 17(1): 55 | | [Pubmed] | [DOI] | | | 14 |
Diagnostic, therapeutic and anesthetic particularities in the approach of giant vascular sinonasal tumors |
|
| Mihail Tusaliu, Iulia Tita, Diana Tuas, Ruxandra Zarei, Cristian Bucur, Badeanu Andreea | | ORL.ro. 2021; 3(52): 6 | | [Pubmed] | [DOI] | | | 15 |
Haemangioma Successfully Treated in a Bitch with Mercurius solubilis: A Case Report |
|
| Álvaro Millán Macías | | Homœopathic Links. 2021; 34(02): 141 | | [Pubmed] | [DOI] | | | 16 |
Brain cavernous hemangioma mimicking radiation-induced necrosis in a patient with non-small cell lung cancer |
|
| Shinkichi Takamori, Takashi Seto, Mikako Jinnouchi, Taichi Matsubara, Naoki Haratake, Naoko Miura, Ryo Toyozawa, Masafumi Yamaguchi, Mitsuhiro Takenoyama | | Thoracic Cancer. 2020; 11(7): 2056 | | [Pubmed] | [DOI] | | | 17 |
Hémangiomatose multifocale bronchique, ganglionnaire, splénique et osseuse |
|
| J. Ancel, J.M. Perotin, M. Dewolf, C. Launois, J. Hagenburg, S. Chouabe, F. Lebargy | | Revue des Maladies Respiratoires. 2020; 37(3): 275 | | [Pubmed] | [DOI] | | | 18 |
Infantil hemanjiomlarin tedavisinde topikal beta-blokerlerin etkinligi |
|
| Gökçe Pinar REIS, Ali FETTAH, Ali AKYIGIT, Atilla ÇAYIR, Burcu VOLKAN | | Pamukkale Medical Journal. 2020; | | [Pubmed] | [DOI] | | | 19 |
Subcutaneous hemangioma on nasal dorsum: a case report |
|
| Hamsu Kadriyan, Muhammad Alfian Sulaksana, Didit Yudhanto, I. Gusti Ayu Trisna Aryani, Eka Arie Yuliani, Nurul Endah Ardianti, Moh. Suprayogi, Fathul Djannah | | Journal of Medical Case Reports. 2020; 14(1) | | [Pubmed] | [DOI] | | | 20 |
Cavernous hemangioma of the inferior vena cava: A first case report |
|
| Francisco JosA Flores-Palomar, MarAa JosA Raphael-Garza, Mauricio De-la-Concha-Tiznado, Ivan Lara-Ruiz, Claudio Rene Monte de Oca-Orellana, Antonio Alfeiran-Ruiz | | Case Reports International. 2019; 8(2): 1 | | [Pubmed] | [DOI] | | | 21 |
Infantile haemangioma: their presentation and management |
|
| Sue Ann Chan, Helen M Goodyear | | British Journal of Hospital Medicine. 2015; 76(9): 523 | | [Pubmed] | [DOI] | |
|
|
|
|
|
|
|
|
