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CASE REPORT - MISCELLANEOUS |
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| Year : 2019 | Volume
: 23
| Issue : 4 | Page : 122-125 |
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Rhinocerebral mucormycosis associated with actinomycosis in a diabetic patient: A rare presentation
Sanda Usha Rani1, Yeluri Sivaranjani1, Manchikatla Praveen Kumar2, Guttikonda Venkateswara Rao1
1 Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, Telangana, India
2 Department of Oral Pathology and Microbiology, CKS Teja Dental College, Tirupati, Andhra Pradesh, India
| Date of Submission | 28-Mar-2018 |
| Date of Acceptance | 29-Dec-2018 |
| Date of Web Publication | 22-Feb-2019 |
Correspondence Address:
Sanda Usha Rani
Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, Telangana
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jomfp.JOMFP_77_18
 Abstract | | |
Mucormycosis is an opportunistic fulminant fungal infection which mainly affects the immunocompromised individuals. It begins in the nose and paranasal sinuses due to the inhalation of fungal spores. The common predisposing factors include diabetes mellitus and immunosuppression. Actinomycosis is a bacterial infection caused by nonspore-forming, anaerobic or microaerophilic bacterial species of the genus Actinomyces. It is a suppurative and chronic granulomatous disease characterized by abscess formation, tissue fibrosis and draining sinuses rarely diagnosed in humans. A case of rhinocerebral mucormycosis associated with actinomycosis of the maxilla involving the palate in an uncontrolled diabetic patient is reported.
Keywords: Actinomycosis, diabetes mellitus, maxilla, mucormycosis
How to cite this article:
Rani SU, Sivaranjani Y, Kumar MP, Rao GV. Rhinocerebral mucormycosis associated with actinomycosis in a diabetic patient: A rare presentation. J Oral Maxillofac Pathol 2019;23, Suppl S1:122-5 |
How to cite this URL:
Rani SU, Sivaranjani Y, Kumar MP, Rao GV. Rhinocerebral mucormycosis associated with actinomycosis in a diabetic patient: A rare presentation. J Oral Maxillofac Pathol [serial online] 2019 [cited 2022 May 19];23, Suppl S1:122-5. Available from: https://www.jomfp.in/text.asp?2019/23/4/122/252738 |
| Introduction | |  |
Mucormycosis is an opportunistic fungal infection caused by fungi of the order Mucorales.[1] The first case of mucormycosis was reported by Paultauf in 1885.[2] These infections are usually noticed in individuals with immunocompromised status and they generally have uncontrolled diabetes mellitus, hematological malignant disease like leukemia or are on immunosuppressive therapy.[1]
Mucormycosis represents the third most common angioinvasive fungal infection.[3] This fungus occurs in soil, manure, vegetable, fruits and as bread mold.[4] The infection begins in the nose and paranasal sinuses (PNSs) due to the inhalation of fungal spores. The infection can spread to orbital and intracranial structures either by direct invasion or through the blood vessels.[5] The fungus invades arteries leading to thrombosis that subsequently causes necrosis of hard and soft tissues.[6]
Actinomycosis in man was first described by Von Langebeck, in 1845 which was attributed to a fungus. Later in the 1960s, Waksman showed that Actinomyces was a Gram-positive bacteria.[7] Actinomycosis is a suppurative and chronic granulomatous disease characterized by abscess formation, tissue fibrosis and draining sinuses rarely diagnosed in humans.[7],[8] It is caused by nonspore-forming, anaerobic or microaerophilic bacterial species of the genus Actinomyces.[8] It is caused by traumas of the orofacial region, extraction of a tooth or through an infected pulp cavity.[9]
A rare case with combination of rhinocerebral mucormycosis associated with actinomycosis of the maxilla in a 63-year-old male patient with uncontrolled diabetes is reported.
| Case Report | | |
A 63-year-old male reported to the outpatient department with a complaint of bad breath and pain in the upper right back teeth region for 3 months. Initially, the patient was asymptomatic and then gradually noticed radiating pain to the upper jaw, nose region and the forehead. The patient is a known diabetic and hypertensive for 2 years and is under medication. Dental history revealed that he underwent extraction 15 years back. No relevant family history was reported.
Extraoral examination revealed a diffused swelling with ill-defined borders [Figure 1]. Bilateral submandibular lymph nodes were palpable, which were firm and tender on palpation. | Figure 1: Extraoral picture revealing diffused swelling with ill-defined borders
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Intraoral examination revealed bone erosion of the maxillary arch with pseudomembranous slough. Necrotic bone was seen in the region of the palate and in the maxilla region extending from 18 to 26 region, and exposure of palate in the midline was also noticed. Missing teeth seen in relation to 11, 12, 13, 14, 15, 17, 18, 21, 22, 23, 25 and 28 [Figure 2]. | Figure 2: Intraorally necrotic bone was seen in the region of the palate with bony erosion of the maxillary arch
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Investigations were performed. The patient's blood glucose levels were tested and the fasting blood glucose level was found to be 230 mg/dl, whereas the postprandial blood glucose level was 380 mg/dl. Computerized tomography scan revealed erosion of anterior maxilla and midpalatal region [Figure 3]. PNS view revealed moth-eaten appearance involving the upper anterior alveolar ridge [Figure 4]. | Figure 3: Computerized tomography scan revealed erosion of the anterior maxilla and midpalatal regions
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 | Figure 4: Paranasal sinus view revealed moth-eaten appearance involving the upper anterior alveolar ridge
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An incisional biopsy was performed. Histopathological examination revealed numerous thick-walled, irregularly branching nonseptate hyphae in the background of necrotic tissue at the periphery of the bony trabeculae [Figure 5]a and was seen invading into the small blood vessels, which is suggestive of mucormycosis, and the tissue showed a peripheral band of fibrosis encasing a zone of chronically inflamed granulation tissue surrounding large collections of polymorphonuclear leukocytes and colonies of microorganisms. These colonies consist of club-shaped filaments that form a radiating rosette pattern suggesting actinomycosis [Figure 5]b. Surgical excision of necrotic bone and adjacent soft tissue was done and sent for histopathological examination [Figure 6]. Histopathologic findings were in accordance with the incisional biopsy, and a final diagnosis of mucormycosis associated with actinomycosis was given. | Figure 5: (a) Histopathology revealing numerous thick-walled, irregularly branching nonseptate hyphae in the background of necrotic tissue. (b) Club-shaped filaments forming a radiating rosette pattern
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| Discussion | | |
Mucormycosis is the third invasive mycosis caused by fungi of the class zygomycetes.[3] Based on the clinical presentation and anatomic site, mucormycosis can be divided into at least six clinical categories: (1) rhino-orbito-cerebral (44%–49%), followed by (2) cutaneous (10%–19%), (3) pulmonary (10%–11%), (4) disseminated (6%–11%), (5) gastrointestinal (2%–11%) and (6) miscellaneous.[5],[10] Mucormycosis is caused by Rhizopus arrhizus species. Mucormycosis in diabetic patients has the ability to produce enzyme ketoreductase which later utilizes patient's ketone bodies for their nutrition.[6]
Rhinocerebral mucormycosis usually present with malaise, headache, facial pain, swelling and low-grade fever. The disease usually begins in the nasal mucosa or palate and extends to the PNSs spreading through the surrounding vessels.[11] If it invades the mouth, a black, necrotic eschar is found on the palate, and ischemic, necrotic turbines may be found in the nose.[12] In addition, mucormycosis can involve the retro-orbital region by direct extension. As mucormycosis develops, the fungal hyphae start to invade local tissue.[11]
Mucormycosis of the oral cavity can originate from disseminated infection where the portal of entry is by inhalation (usually through the nose) or can also result from direct wound contamination with dissemination to other viscera as a common complication. When arising from the nose and PNSs, the infection may cause palatal ulceration progressing to necrosis.[13]
Histologically, mucormycosis is characterized by extensive tissue necrosis and the presence of numerous, large (5–30 μm), thin-walled fungal hyphae, which are nonseptate, branched at right angles and have a ribbon-like appearance.[12] There is a close histopathological resemblance between the fungal hyphae of mucormycosis and aspergillosis. The differentiating feature is that the hyphae of mucormycosis are nonseptate and branch at right angles, whereas the hyphae of aspergillus species are septate, smaller in width and branch at more acute angles.[3]
The Actinomyces species are Gram-positive, pleomorhic and diphtheroidal, or more commonly, delicately filamentous. The cervicofacial, thoracic and abdominopelvic regions and central nervous system are most commonly involved in actinomycosis. Actinomycosis usually occurs in immunocompetent persons but may occur in persons with diminished host defenses.[8]
The common initial symptoms of infection are sudden onset of cervicofacial pain, swelling, erythema, edema and suppuration. Rarely regional lymphadenopathy is seen. However, lymphadenopathy and abscess formation are seen due to secondary infection.[9] Cervicofacial actinomycosis is the most common form of actinomycosis. The most commonly involved sites are submandibular space, cheek, parotid gland, teeth, tongue, nasal cavity, gingiva, etc.[7] In general, the disease has a peak incidence in the fourth to sixth decades of life with a slight male predominance. The mandible is more commonly involved than maxilla (4:1).[14] Similarly, this patient was of middle age. Although this case was immunocompetent, actinomycosis has a predilection for causing infection in immunocompromised hosts such as malignancy, immunosuppressive drugs and diabetes.
Sulfur granules, biopsy regimens and pathologic investigation are the most significant factors in the diagnosis of actinomycosis.[7],[9] In the present case, we could not demonstrate sulfur granules probably because the infection was just transitory between the acute and chronic forms, and the mineralization might not have taken place. Further, the periphery of the central core of the rosette stained basophilic, whereas the peripheral clubs stained eosinophilic red. This established finding from other studies helped us to arrive at a definitive diagnosis.
| Conclusion | | |
In summary, we present a complicated association of two uncommon diseases. Mucormycosis is a rare condition which may pose a diagnostic challenge for dental surgeons who may not be familiar with its clinical presentations. Actinomycotic infections of the cervicofacial region are uncommon, but they are important in dental practice because they may mimic more common oral disease, primarily dental-related infection mimicking a malignant disease. Hence, a proper understanding of such infections is needed as the underlying systemic conditions at many times may be quiescent and dentists may identify the debilitated status of the patient.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | | |
| 1. | Pandey A, Bansal V, Asthana AK, Trivedi V, Madan M, Das A, et al. Maxillary osteomyelitis by mucormycosis: Report of four cases. Int J Infect Dis 2011;15:e66-9.  |
| 2. | Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, et al. Epidemiology and outcome of zygomycosis: A review of 929 reported cases. Clin Infect Dis 2005;41:634-53. |
| 3. | Khan S, Jetley S, Rana S, Kapur P. Rhinomaxillary mucormycosis in a diabetic female. J Cranio Maxillary Dis 2013;2:91-3. |
| 4. | Sujatha RS, Rakesh N, Deepa J, Ashish L, Shridevi B. Rhino cerebral mucormycosis. A report of two cases and review of literature. J Clin Exp Dent 2011;3:e256-60. |
| 5. | Garlapati K, Chavva S, Vaddeswarupu RM, Surampudi J. Fulminant mucormycosis involving paranasal sinuses: A rare case report. Case Rep Dent 2014;2014:465919. |
| 6. | Sreenath G, Prakash AR, Kanth MR, Reddy PS, Vidhyadhari P. Rhinomaxillary mucormycosis with palatal perforation: A case report. J Clin Diagn Res 2014;8:ZD01-3. |
| 7. | Lancella A, Abbate G, Foscolo AM, Dosdegani R. Two unusual presentations of cervicofacial actinomycosis and review of the literature. Acta Otorhinolaryngol Ital 2008;28:89-93. |
| 8. | Smego RA Jr., Foglia G. Actinomycosis. Clin Infect Dis 1998;26:1255-61. |
| 9. | Guvercin M, Gurler G, Goktay O, Kadir T, Gursoy B. Cervicofacial actinomycosis: A case report. Oral Health Dent Manage Black Sea Countries 2005;4:58-61. |
| 10. | Jayachandran S, Kumar MS. Rhino orbital mucormycosis: Clinical and radiological evaluation for prognostic assessment – Case series. Univ J Pharm 2013;2:25-8. |
| 11. | Bakathir AA. Mucormycosis of the jaw after dental extractions: Two case reports. Sultan Qaboos Univ Med J 2006;6:77-82. |
| 12. | Hingad N, Kumar G, Deshmukh R. Oral mucormycosis causing necrotizing lesion in a diabetic patient. A case report. Int J Oral Maxillofac Pathol 2012;3:8-12. |
| 13. | Vijayabala GS, Annigeri RG, Sudarshan R. Mucormycosis in a diabetic ketoacidosis patient. Asian Pac J Trop Biomed 2013;3:830-3. |
| 14. | Rathnaprabhu V, Rajesh R, Sunitha M. Intraoral actinomycotic lesion: A case report. J Indian Soc Pedod Prev Dent 2003;21:144-6. [ PUBMED] |
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
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