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| ORIGINAL ARTICLE |
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| Year : 2021 |
Volume
: 25 | Issue : 2 | Page
: 226-231 |
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Analysis of ENAM gene single-nucleotide polymorphism rs3796704 with caries susceptibility in young adult Tamil population
Niveditha Thampan1, R Ramya2, R Swarnalakshmi3, K Rajkumar1, S Savithri4, G Divyalakshmi1
1 Department of Oral and Maxillofacial Pathology, SRM Dental College, Chennai, Tamil Nadu, India
2 Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Chennai, Tamil Nadu, India
3 Department of Stomatognathic Function and Occlusal Reconstruction, Tokushima University, Tokushima, Japan
4 Department of Microbiology, SRM Dental College, Chennai, Tamil Nadu, India
Correspondence Address:
Niveditha Thampan
Department of Oral and Maxillofacial Pathology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai - 600 089, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-029X.325119
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Background: Dental caries is as primeval as humanity, but still, investigations are undergoing regarding the etiopathogenesis behind this multifactorial disease. Genetics is known to play a vital role in the etiology behind dental caries in addition to environmental and socioeconomic factors. Genetic variations like single-nucleotide polymorphisms (SNPs) were extensively studied in the past decade to portray the etiopathogenesis contributing to dental caries.
Aim: This investigation was undertaken to analyze the ENAM gene SNP rs3796704 with caries susceptibility in ethnic young adult Tamil population of India.
Materials and Methods: Out of 370 patients included, 215 patients belonged to the high caries group (Decayed, Missing and Filled Tooth [DMFT] ≥2) and 155 patients belonged to the low caries group (DMFT ≤ 1). DNA was extracted from the blood of all the individuals. SNP genotyping was performed utilizing tetra-primer amplification refractory mutation system–polymerase chain reaction with specific primers.
Results: The genotyping results showed that there were no differences in allelic (P = 0.114) and genotypic frequencies (P = 0.159) between the high caries and low caries groups.
Conclusion: Future studies can be conducted in larger samples and different ethnicities around the globe to analyze the role played by SNPs of enamel formation genes in cariogenesis.
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