Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ONLINE ONLY ARTICLES - ORIGINAL ARTICLE Table of Contents   
Year : 2021  |  Volume : 25  |  Issue : 2  |  Page : 368
Comparison of orosomucoid-1 immunoexpression and angiogenesis between oral squamous cell carcinoma cases with different histological grades


1 Molecular Pathology Area, School of Dentistry, University of the Republic, Montevideo, Uruguay; Department of Research, School of Dentistry, Juarez University of the State of Durango, Durango, México
2 Department of Research, School of Dentistry, Juarez University of the State of Durango, Durango, México
3 Department of Anatomical Pathology, National Institute of Oncology and Radiobiology, Havana, Cuba; Department of Anatomical Pathology, Society to Fight Cancer, Núcleo Manabí
4 Department of Oral Pathology Research, School of Dentistry, University of San Gregorio Portoviejo, Portoviejo, Manabí, Ecuador

Correspondence Address:
Nataly Barreiro Mendoza
Department of Oral Pathology Research, School of Dentistry, University of San Gregorio Portoviejo, Av. Metropolitana 2005, 130101, Portoviejo, Manabí
Ecuador
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.325243

Rights and Permissions

Background: Oral squamous cell carcinoma (OSCC) is the most common malignancy in this region, and thus, further elucidation of its tumoral mechanisms is important. One of the main roles of the acute-phase protein orosomucoid-1 (ORM1) is the promotion of angiogenesis, which is key for tumor nutrition and growth. Aim: Our aim was to evaluate the immunohistochemical expression of ORM1 and the angiogenic activity indicated by microvascular density (MVD) in OSCC samples according to histological grade. Materials and Methods: Formalin-fixed, paraffin-embedded sections from 45 OSCC cases were submitted to immunohistochemistry: 25 were well-differentiated OSCC, 18 were moderately differentiated OSCC and 2 were poorly differentiated OSCC. ORM1 staining was evaluated by a semiquantitative method, and CD34-positive blood vessels were quantified to calculate the MVD. The results were statically analyzed. Results: All cases exhibited immunoexpression of ORM1 and CD34. However, no significant differences were found between the expression of both markers among the histological grades. In addition, the presence of ORM1 in inflammatory cells and in the extracellular matrix was detected in most cases. Conclusion: These results suggest that the induction of angiogenesis is not the main role of ORM1 in OSCC and may be associated with the regulation of the immune/inflammatory response or the transport of protumoral molecules, such as sialyl-Lewis X or phorbol esters, which requires confirmation in future studies.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed200    
    Printed4    
    Emailed0    
    PDF Downloaded40    
    Comments [Add]    

Recommend this journal

 

Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007