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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2021  |  Volume : 25  |  Issue : 3  |  Page : 437-440
The role of salivary lactate levels in assessing the severity of septic shock


1 Departments of Oral and Maxillofacial Pathology, Subbaiah Institute of Dental Sciences, Shivamogga, Karnataka, India
2 Department of Anaesthesiology and Critical Care Medicine, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India
3 Department of Pedodontics, Subbaiah Institute of Dental Sciences, Shivamogga, Karnataka, India
4 Departments of Oral and Maxillofacial Pathology, Faculty of Dentistry, SEGI University, Selangor, Malaysia
5 Department of Oral Pathology and Microbiology, Bengaluru, Karnataka, India

Correspondence Address:
D K Shruthi
SSS Mansion, 1st Main, 3rd Cross, Basaveswara Nagar, Shivamogga 577 201, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.jomfp_199_21

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Background: Sepsis is a major worldwide cause of morbidity and mortality. Hence, rapid and reliable diagnosis is essential. Emergency departments use a standard measure of sepsis, based upon an elevated Lactate level in blood. Saliva is more readily available and easier to obtain than blood samples, and is increasingly being studied as a new source of diagnostic information. Aim: This study aimed to evaluate whether analysis of Lactate levels in saliva can substitute for that of Lactate levels in blood. Methods/Materials: We processed saliva samples and serum samples from septic shock and non-septic shock patients. We found out Lactate levels in both the group. We plotted the concentration of Lactate in non-septic and septic patients and compared lactate levels in saliva to its levels in blood. Statistical analysis: Results were statistically analyzed by independent sample t test and A Spearman rho correlation Results: We found increased serum and salivary Lactate levels in all cases of sepsis compared to the control group. Notably, the increase in Lactate levels was higher in serum as compared to saliva in septic patients, suggesting saliva may not serve as a better indicator of sepsis compared to blood. Salivary lactate was more in septic shock patients compared to non-septic shock patients. Conclusions: To our knowledge, this is the first study to compare lactic acid levels in serum and saliva in cases of sepsis. The increase in serum lactate in patients with sepsis is evident when compared to increase in salivary lactate, so serum lactate level would be easier for physicians to differentiate septic patients from non-septic patients. Salivary lactate may not serve as better indicator in septic shock patients.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007