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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
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Year : 2021  |  Volume : 25  |  Issue : 3  |  Page : 559
Oral amyloidosis: A case report and diagnostic algorithm


1 Division of Oral Pathology, Army Dental Centre (R and R), New Delhi, India
2 Armed Forces Dental Clinic, New Delhi, India
3 Department of Pathology, Army Hospital (R and R), New Delhi, India
4 Department of Hematology, Army Hospital (R and R), New Delhi, India

Correspondence Address:
Sudip Indu
Division of Oral Pathology, Army Dental Centre (R and R), New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_227_20

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Background: Amyloidosis is a distressing and infrequent condition caused by accumulation of abnormally folded proteins as aggregates in the extracellular tissue spaces of the body, leading to destruction of organ structure and function. Presentation of Oral Amyloidosis is generally a rare phenomenon, tongue being the most common site to manifest the disease process. Accurate recognition of the amyloid protein and its sub typing is absolutely critical for clinical management and to assess prognosis such as to avoid misdiagnosis and unwanted, potentially harmful treatment. Case Report: We report a case of 84 year old male patient with an enlarged tongue, who presented with burning sensation and a facial violaceous papules with no other known systemic findings. Incisional biopsy revealed amorphous deposits confirmed for amyloid by congo red stain and Immunohistochemistry. Conclusion: The suspicion of Amyloidosis should always be kept in mind whenever a solitary enlargement of the tongue is noticed. Close follow-up and an entire panel of investigations is mandatory, both to manage recurrences and to monitor the possible advancement of the disease into a full blown systemic form.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007