Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2022  |  Volume : 26  |  Issue : 1  |  Page : 21-25
Role of nano curcumin on superoxide dismutase levels in leukoplakia


1 Department of Oral and Maxillofacial Pathology and Oral Microbiology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India
2 Bio-Nano Scientist, Oncocur India Pvt. Ltd, Pune, Maharashtra, India

Correspondence Address:
Sunanda Deb
Department of Oral and Maxillofacial Pathology and Oral Microbiology, School of Dental Sciences, Sharda University, Knowledge Park-III, Greater Noida, Gautam Budh Nagar-201 308, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.JOMFP_267_21

Rights and Permissions

Introduction: Oral leukoplakia has an estimated prevalence of 2% of the oral cavity, one of the risk factors for oral cancers. The most commonly linked etiology being tobacco smoking causing reactive oxygen species (ROS) induced DNA damage. Curcumin, a polyphenol derivative from herbal remedy, possesses diverse properties ranging from centuries old documented anti-inflammatory properties to recently documented anticancer properties. Aims: Role of nano curcumin on superoxide dismutase (SOD) levels in leukoplakia patients' pre- and post-treatment Materials and Methods: The study group comprised thirty test subjects. Single capsule of 250 mg (Brecan Plus) was given to the test group for 30 days with weekly follow-up. Blood samples were taken from the test group and were evaluated for SOD levels before and after the completion of the trial. Results: In the study, there was a decrease in size of the lesion, number of lesions, down staging of the disease, and increase in serum SOD levels after the therapy. Binary logistic retrogression analysis was done to assess the predictive ability of serum SOD-dependent variable, and a positive association was noted between increase in serum SOD level and down staging of the disease. Conclusion: Nano curcumin is an excellent medical nutrition intervention derived from traditional natural products. The study has demonstrated the clinical efficacy of these new classes of therapeutic nutraceuticals such as nanocurcumin in treating oral leukoplakia, which are suitable for long-term use.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed272    
    Printed2    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal

 

Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007