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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2022  |  Volume : 26  |  Issue : 2  |  Page : 166-172
Role of S100 A7 as a diagnostic biomarker in oral potentially malignant disorders and oral cancer


1 Department of Oral Pathology and Microbiology, Centre for Dental education and Research, All India Institute of Medical Sciences, Delhi, India
2 Centre for Dental education and Research, All India Institute of Medical Sciences, Delhi, India
3 Department of Biochemistry, All India Institute of Medical Sciences, Delhi, India
4 Department of BiochemistryPathology, All India Institute of Medical Sciences, Delhi, India
5 Department of Surgical Oncology, All India Institute of Medical Sciences, Delhi, India
6 Department of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences, Delhi, India
7 Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada

Correspondence Address:
Deepika Mishra
Department of Oral Pathology and Microbiology, Centre for Dental education and Research, All India Institute of Medical Sciences, Delhi - 110 029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.jomfp_402_20

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Background: S100 proteins have been implicated in the tumorigenesis of different human cancers and in oral dysplasia, as they are keratinocytes. Materials and Methods: In the present study, we have attempted to compare the expression of S100-A7 within young-onset (age ≤45 years, Group 1) oral squamous cell carcinoma (OSCC), OSCC in older age groups (age >45 years Group 2), oral potentially malignant disorders (OPMDs, Group 3) and inflammatory lesions (Group 4). The tissue sections were scored based on the percentage of immunostained cells and staining intensity. Nuclear, cytoplasmic and membrane immunoreactivity were also scored. Results: The present study comprised 153 histopathologically diagnosed case subjects of OSCC >45 years (n = 41), OSCC <45 years (n = 36), OPMD (n = 40) and inflammatory lesions (n = 36). The present study revealed a statistically significant difference of distribution with regard to S100A7 staining (cytoplasmic and nuclear) between OPMDs and OSCC (P < 0.05). The nuclear, cytoplasmic and membrane staining as well as the staining intensity had significantly different scoring patterns among the OSCC group, OPMD group and the inflammatory lesions with the OSCC group having the highest scoring of the S100A7 staining (irrespective of the age). Conclusions: The present study concludes that S100A7 can be used as a diagnostic biomarker to differentiate between OPMDs and OSCC lesions. However, the marker is unable to distinguish between OSCCs in younger and older patients as the molecular pathogenesis of tumors in either of these age groups is probably similar.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007