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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2022  |  Volume : 26  |  Issue : 3  |  Page : 335-339
Utility of serum homocysteine in oral squamous cell carcinoma patients as a potential biomarker

1 Department of Oral Pathology and Microbiology, Sinhgad College of Engineering, Pune, Maharashtra, India
2 Department of Biotechnology, Sinhgad College of Engineering, Pune, Maharashtra, India
3 Public Health Dentistry, Sinhgad Dental College and Hospital, Pune, Maharashtra, India

Correspondence Address:
Rasika Pawar
Sinhgad Dental College and Hospital, 44/1 off Sinhgad Road, Vadgao (Bk), Pune - 411 041, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.jomfp_268_22

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Background: In India, Oral cancer is one of the most common cancers. Despite advances in treatments, prognosis for oral cancer has remained poor with a five-year survival rate of 40–50%. Therefore, it is necessary to develop effective diagnostic methods for early diagnosis and better prognosis. Homocysteine (Hcy) has been reported as a 'tumour marker' in various cancers such as breast cancer, colorectal cancer, lung cancer, cervical cancer. Aim: To study the levels of serum Hcy in oral squamous cell carcinoma (OSCC) patients. Objectives: To assess the clinical utility of serum Hcy as a potential tumour marker for OSCC cases. Methodology: Serum Hcy levels were studied and compared between patients with OSCC and healthy individuals. Results: Serum Hcy levels were higher in patients having OSCC. Conclusion: Serum Hcy levels could be utilized as a biological marker in the diagnosis and the prognosis of OSCC patients.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007