Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
  Table of Contents    
BRIEF COMMUNICATION  
Year : 2022  |  Volume : 26  |  Issue : 3  |  Page : 392-394
 

Transepidermal elimination of suture material in lip biopsy specimen


1 Department of Oral Pathology, Dharmsinh Desai University, Nadiad, Gujarat, India
2 General Surgery, Consultant Surgeon, Gujarat Surgical Hospital, Vadodara, Gujarat, India
3 Department of Oral and Maxillofacial Pathology, VS Dental College and Hospital, Bengaluru, Karnataka, India
4 Department of Medicine, SSG Medical College, Vadodara, Gujarat, India

Date of Submission24-May-2022
Date of Acceptance26-Jul-2022
Date of Web Publication17-Oct-2022

Correspondence Address:
Himani Tiwari Chaturvedi
A1/57, Darshanam Greens, BH Baroda Public School 2, Near Nathdwara Residency, Dabhoi Waghodia Ring Road, Vadodara - 390 019, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.jomfp_229_22

Rights and Permissions

 

   Abstract 


Transepidermal elimination (TE) is a well-known phenomenon by which dermal materials are expelled through an active epithelial-dermal connective tissue interaction. It has been associated with many cutaneous disorders and described as a regular or sporadic occurrence in a variety of dermatologic conditions. TE as a means of expulsion by skin, either externally introduced or endogenously generated foreign material, is well recognized but rarely appreciated phenomenon. Hence, here we are presenting a case of TE of suture material from the labial surface of the lower lip in a patient who was previously operated for mucocele a year back and reported with the impression of the recurrent lesion.


Keywords: Lip, suture material, transepidermal elimination


How to cite this article:
Chaturvedi HT, Chaturvedi C, Thammaiah S, Patel V. Transepidermal elimination of suture material in lip biopsy specimen. J Oral Maxillofac Pathol 2022;26:392-4

How to cite this URL:
Chaturvedi HT, Chaturvedi C, Thammaiah S, Patel V. Transepidermal elimination of suture material in lip biopsy specimen. J Oral Maxillofac Pathol [serial online] 2022 [cited 2022 Dec 7];26:392-4. Available from: https://www.jomfp.in/text.asp?2022/26/3/392/358725





   Introduction Top


Transepidermal elimination (TE) is a purposeful, well known, reactive phenomenon by which foreign or altered dermal constituents are removed via the epidermis. Altered dermal constituents may be due to the consequences of inflammatory, metabolic, or neoplastic disorders.[1],[2] Mehregan first coined the term TE in 1970 and proposed the concept of it in a variety of dermatologic conditions.[3],[4] TE of suture material shows the natural cutaneous waste disposal mechanism of foreign material.


   Case Details Top


A 35-year-old male presented to our hospital with slow growing, non-tender, soft lesion on the labial surface of the lower lip with a smooth surface for the last 4 months. He had a history of mucocele at the same site which was operated a year back. On intraoral examination, a solitary well defined, oval-shaped swelling measuring about 1.0 × 0.9 cm in size on the labial surface of the lower right side of the lip with normal overlying mucosa and without any lymphadenopathy. Differential diagnosis includes recurrent mucous extravasation phenomenon, mucous retention cyst, lipoma, and salivary gland tumors.

The lesion was completely excised under local anesthesia with the clinical impression of recurrent mucocele and primary closure done. Grossly the lesion has an intact epithelial surface and measured 1.0 cm in greatest dimension. Microscopically lesion shows hyperplastic proliferating epithelium with acanthosis, extending into the lamina propria and surrounding the abundant foreign body suture material. Suture material appears as multiple circular and oval bodies (depending on the cut section) and shows birefringence under the polarizer [Figure 1],[Figure 2],[Figure 3]. Underlying connective tissue was richly vascularized along with multiple neutrophils and macrophages. The lesion was diagnosed as TE of suture material.
Figure 1: Photomicrograph shows suture material (←) enveloping by epithelium. (a) original magnification hematoxylin and eosin stain-4 (H&E-4×), (b) H&E-10×

Click here to view
Figure 2: Photomicrograph shows suture material as circular and oval body depending on cut section. Some suture material is cut in cross section (black arrow) and some in longitudinal section (red arrow). (a and b) original magnification H&E-40×

Click here to view
Figure 3: Photomicrograph of the same field [Figure 2] under polarizer. (a and b - original magnification H&E-40×)

Click here to view


Definition

TE is well recognized histopathologic phenomenon and allows the disposal of foreign material by epithelium without gross disturbance in epidermal integrity. It is characterized by pseudoepitheliomatous hyperplasia of epidermis and/or follicular epithelium and formation of multiple transepithelial perforating channels, facilitating the extrusion of the altered dermal material or foreign substances to the exterior.[1],[2],[3],[4]

Pathogenesis and concept of TE-

Mehregan described three different types of epidermal reaction depending on the quality, quantity, and particle size of the foreign matter.[1],[2],[5]

Type 1 includes the trapping of nonmotile cells or inert particles such as erythrocytes and hemosiderin, respectively, which elicit minimal or no dermal reaction. These particles can be trapped between epithelial cells and migrate upward to the surface and lead to desquamation.

Type 2 reaction involves motile cells such as Treponema pallidum and leukocytes which actively migrate into the epidermal spaces to be carried upward with physiological desquamation process.

Type 1 and type 2, being relatively passive processes with the absence of specific dermoepidermal reaction, have collectively been known as “transmigration.”

Type 3 includes active epidermal-dermal interaction which is a unidirectional elimination process whereby dermal altered material and foreign components (e.g., calcium, collagen, elastin) are actively eliminated through the epidermis. Mehregan formulates this concept and coined the term as “TE.”

Nature and location of dermal stimulus are the two main prerequisites for TE. The stimulus should not be very strong otherwise it elicits a strong inflammatory reaction which leads to necrosis and purulent discharge which does not represent transepithelial elimination. Hence, the stimulus should be irritant enough to induce reactive hyperplasia of the epidermis and inflammation without any major structural alteration. The stimulus should be located within a specific dermal–epidermal interaction zone that is above the level of the hair papillae in the dermis. Close proximity to the epithelium is extremely required because the deeper location of the stimulus will not result in TE.[1],[2]

Although pathogenesis and molecular mechanism of TE are not fully understood. The initial event starts with the binding of foreign or altered dermal constituents to an unidentified receptor followed by dermal production of some chemical mediators leading to hyperproliferation of the epidermis. The formation of transepidermal channels takes place and foreign substances get surrounded and phagocytosed by epidermal cells then and are subsequently moved upward to the surface. Recently, in the pathogenesis of acquired reactive perforating collagenosis, the receptor for advanced glycation end products has been suggested to play a role by modulating the collagen–keratinocyte interaction and keratinocyte migration.[1],[3]

Disorders associated with TE

TE has been characteristically presented as the hallmark of primary perforating disorders, namely, elastosis perforans serpiginosa, reactive perforating collagenosis, perforating folliculitis, and acquired perforating dermatosis.[1],[6] TE is also described in many infective and noninfective conditions and may present as perforating folliculitis.[1],[7],[8] TE of gold metals has been reported after the procedure of face-lifting acupuncture.[9]

The materials undergoing elimination may be foreign (calcium, silica, and topical steroids), infective (chromomycosis, cryptococcosis, aspergillosis, and leishmaniasis), altered connective tissue components (sarcoidosis, granuloma annulare, necrobiosis lipoidica, rheumatoid nodule, pseudoxanthoma elasticum, and healing wounds), inflammatory cells and erythrocytes (black heel hemorrhage), neoplastic cells (melanoma, Paget disease, and mycosis fungoides), products of keratinization or extracellular substances (amyloid protein, uric acid, mucin, and sialomucin).[3]

Reports have been published of transepithelial elimination of retained suture material via hair follicle in a woman who was operated for basal cell carcinoma on tip of the nose.[4] TE has also been described as a cutaneous waste disposal mechanism for foreign material, like suture, talcum powder, and Monsel's solution (ferric subsulfate).[5] The concept of TE was supported and recorded in the animal model, in which charcoal particles were injected into the skin of guinea pigs.[4],[5],[10]

Here, the patient was operated for mucocele on the lower lip 1 year back and developed the swelling at the same site, mitigating as recurrent mucocele, hence re-excised and sent for histopathology which showed TE of suture material.


   Conclusion Top


Transepithelial elimination is common, unreported, and well-accepted histological phenomenon of elimination of debris from the dermis via the epidermis or hair follicle which signifies the skin's remarkable self-healing potential. This entity should always be kept in mind while dealing with lesions previously operated and mimicking recurrence or missed malignancy. Thus, this case discussion elaborates on the histomorphological appearance of TE of suture material, which will help pathologists in accurate diagnosis and hence surgical interventions.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Shah H, Tiwary AK, Kumar P. Transepidermal elimination: Historical evolution, pathogenesis and nosology. Indian J Dermatol Venereol Leprol 2018;84:753-7.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Woo TY, Rasmussen JE. Disorders of transepidermal elimination. Part 1. Int J Dermatol 1985;24:267-79.  Back to cited text no. 2
    
3.
Ismail A, Beckum K, McKay K. Transepithelial elimination in sarcoidosis: A frequent finding. J Cutan Pathol. 2014;41:22-7.  Back to cited text no. 3
    
4.
Goette DK. Transepithelial elimination of suture material. Arch Dermatol 1984;120:1137-8.  Back to cited text no. 4
    
5.
Goette DK. The significance of transepithelial elimination in dermatologic surgery. J Dermatol Surg Oncol 1986;12:608-13.  Back to cited text no. 5
    
6.
Harbaoui S, Litaiem N. Acquired perforating dermatosis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.  Back to cited text no. 6
    
7.
Miranda MF, Costa VS, Bittencourt Mde J, Brito AC. Transepidermal elimination of parasites in Jorge Lobo's disease. An Bras Dermatol 2010;85:3943.  Back to cited text no. 7
    
8.
Puig L, Pradinaud R. Leishmania and HIV coinfection: Dermatological manifestations. Ann Trop Med Parasitol 2003;97(Suppl 1):10714.  Back to cited text no. 8
    
9.
Keum DI, Bak H, Ahn SK. Transepidermal elimination of gold metals after face-lifting acupuncture. Ann Dermatol 2016;28:501-2.  Back to cited text no. 9
    
10.
Bayoumi AH, Marks R. Transepidermal elimination: Studies with an animal model. Br J Exp Pathol 1980;61:5606.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

Top
Print this article  Email this article
            

    

 
   Search
 
  
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Article in PDF (1,344 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
   Introduction
   Case Details
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed172    
    Printed2    
    Emailed0    
    PDF Downloaded27    
    Comments [Add]    

Recommend this journal

Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007