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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2022  |  Volume : 26  |  Issue : 4  |  Page : 604
A study on genetic and mutans streptococcal transmissibility of dental caries


1 Department of Oral and Maxillofacial Pathology, Yamuna Institute of Dental Sciences and Research, Yamuna Nagar, Haryana, India
2 Former Vice-chancellor, M. M. (Deemed to be) University, Mullana, Ambala, Haryana, India
3 Former Principal, MM College of Dental Sciences and Research, M. M. (Deemed to be) University, Mullana, Ambala, Haryana, India

Correspondence Address:
Shailja Chatterjee
Oral Cancer Screening and Diagnostic Centre, 3/1323, Chatterjee Cottage, Janak Nagar, Saharanpur, Uttar Pradesh - 247 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jomfp.jomfp_201_22

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Background: Dental caries is characterized by an interplay between environmental and genetic factors. Aim: The aim of this study was to analyse the transmissibilities of high caries risk chromosomal loci at 5q 12.1-13.3 and low caries risk chromosomal loci at 13q31.1 and Streptococcus mutans (S. mutans) in family units. Materials: This prospective cohort study was performed on 56 families grouped into four: (a) Group I: 18 families of children with caries affected primary teeth; (b) Group II: 21 families of children with caries in permanent teeth; (c) Group III: 6 families of children with no caries in primary teeth and (d) Group IV: 12 families of children with no caries in permanent teeth. Blood, saliva and plaque samples were collected from consenting study participants. Isolated DNAs were subjected to polymerase chain reactions using suitable primers. Data collected was analysed with ANOVA and Chi-squared test. Results: Wide expression of chromosome loci 5q12.1-13.3 was obtained in both blood and saliva samples. For chromosome loci 13q31.1, no expression was found in saliva samples, hence indicating its local absence. For the GtfB expression, transmissibility was common for a single band expressing S. mutans. Conclusion: This study reflects upon newer findings in the field of genetic research on dental caries.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007