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| CASE REPORT |
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| Year : 2022 |
Volume
: 26 | Issue : 5 | Page
: 133-138 |
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Management of oral leukoplakia in patients with Fanconi anemia
Roberto Pippi1, Cira Di Gioia2, Ursula La Rocca3, Amelia Bellisario1, Anna Paola Iori3
1 Department of Oral and Maxillofacial Sciences, Division of Oral Surgery, “Sapienza” University, Rome, Italy
2 Department of Radiological, Oncological and Pathological Anatomy Sciences, Division of Pathological/Cardiovascular Anatomy and Histology, “Sapienza” University, Rome, Italy
3 Department of Translational and Precision Medicine, Division of Allogeneic Transplantation, “Sapienza” University of Rome, Rome, Italy
Correspondence Address:
Roberto Pippi
Department of Oral and Maxillofacial Sciences, “Sapienza” University of Rome, Via Caserta 6-00161, Roma
Italy
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jomfp.jomfp_280_21
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Fanconi anemia (FA) is a rare genetic disease involving an increased risk of developing acute myeloid leukemia and solid tumors, especially head-and-neck squamous cell carcinomas, for which the oral cavity is the most frequent site of occurrence. The patient presented in this study underwent allogeneic hematopoietic stem cell transplantation (HSCT) and developed nonhomogeneous oral leukoplakia after 7 years, which was promptly removed and diagnosed with high-grade epithelial dysplasia. Many risk conditions for oral squamous cell carcinoma were featured in the present case including FA, allogeneic HSCT, graft-versus-host disease, immunosuppressive therapy, female gender, nonsmoker, tongue location and nonhomogeneous type of leukoplakia. Close follow-up of the entire upper aerodigestive tract mucosa and early removal of all suspected lesions are highly recommended in the management of such patients.
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