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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

CASE REPORT Table of Contents   
Year : 2022  |  Volume : 26  |  Issue : 5  |  Page : 133-138
Management of oral leukoplakia in patients with Fanconi anemia

1 Department of Oral and Maxillofacial Sciences, Division of Oral Surgery, “Sapienza” University, Rome, Italy
2 Department of Radiological, Oncological and Pathological Anatomy Sciences, Division of Pathological/Cardiovascular Anatomy and Histology, “Sapienza” University, Rome, Italy
3 Department of Translational and Precision Medicine, Division of Allogeneic Transplantation, “Sapienza” University of Rome, Rome, Italy

Correspondence Address:
Roberto Pippi
Department of Oral and Maxillofacial Sciences, “Sapienza” University of Rome, Via Caserta 6-00161, Roma
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jomfp.jomfp_280_21

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Fanconi anemia (FA) is a rare genetic disease involving an increased risk of developing acute myeloid leukemia and solid tumors, especially head-and-neck squamous cell carcinomas, for which the oral cavity is the most frequent site of occurrence. The patient presented in this study underwent allogeneic hematopoietic stem cell transplantation (HSCT) and developed nonhomogeneous oral leukoplakia after 7 years, which was promptly removed and diagnosed with high-grade epithelial dysplasia. Many risk conditions for oral squamous cell carcinoma were featured in the present case including FA, allogeneic HSCT, graft-versus-host disease, immunosuppressive therapy, female gender, nonsmoker, tongue location and nonhomogeneous type of leukoplakia. Close follow-up of the entire upper aerodigestive tract mucosa and early removal of all suspected lesions are highly recommended in the management of such patients.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007