Journal of Oral and Maxillofacial Pathology

ORIGINAL RESEARCH
Year
: 2003  |  Volume : 7  |  Issue : 2  |  Page : 40--43

Monoclonal antibody to desmosomal antigen Dsg1: A reliable adjunct to histopathology


Simarpreet Virk1, Alka Kale2 
1 Senior lecturer in Oral Pathology, SGRD Inst. of Dental Sciences, Amritsar, India
2 Department of Oral Pathology, KLES Inst. of Dental Sciences and Research, Belgaum, India

Correspondence Address:
Simarpreet Virk
883-Circular Road, Amritsar, Punjab
India

Desmosomes are cell surface modifications that provide strong adhesion between epithelial cells. The presence of desmosomes in a majority of epithelia make them useful epithelial markers. This paper describes a monoclonal antibody 32-2B to desmosomal glycoprotein 1 (Dsg1) or desmoglein, preserved in routinely processed paraffin embedded sections. This antibody was tested for its ability to stain normal oral epithelium and epithelium derived tumors. It reacted with all oral epithelial specimens tested but showed negative staining in those specimens which lacked desmosomal structures like connective tissue cells and lymph nodes. These characteristics demonstrate that 32-2B is a reliable epithelial marker that may be useful in diagnostic histopathology.


How to cite this article:
Virk S, Kale A. Monoclonal antibody to desmosomal antigen Dsg1: A reliable adjunct to histopathology.J Oral Maxillofac Pathol 2003;7:40-43


How to cite this URL:
Virk S, Kale A. Monoclonal antibody to desmosomal antigen Dsg1: A reliable adjunct to histopathology. J Oral Maxillofac Pathol [serial online] 2003 [cited 2022 May 22 ];7:40-43
Available from: https://www.jomfp.in/article.asp?issn=0973-029X;year=2003;volume=7;issue=2;spage=40;epage=43;aulast=Virk;type=0