Journal of Oral and Maxillofacial Pathology

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 15  |  Issue : 2  |  Page : 168--176

A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis


M Akhter, S Hossain, Quazi B Rahman, Motiur R Molla 
 Department of Oral and Maxillofacial Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Correspondence Address:
M Akhter
Department of Oral and Maxillofacial Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka
Bangladesh

Background: Histological grading is an important diagnostic tool to predict the clinical and biological behaviour of cancer. Cervical lymph node metastasis indicate poor prognosis of oral cancer. Considering economical status of a third world country, Anneroth俟Q製 grading system is less expensive, more informative than TNM staging and Broder俟Q製 grading system. Anneroth俟Q製 grading system also shows co-relationship with lymph node metastasis. So we are trying to evaluate the Anneroth俟Q製 grading as a standard one among these three system. Objective: To study the grading of histological malignancy according to Anneroth俟Q製 classification of biopsy specimens in relation to metastasis in the cervical lymph nodes and comparing the Anneroth俟Q製 with the other two recognized classifications. Materials and Methods: Fifty(50) patients with oral squamous cell carcinoma was included in the study. Specimen of 35 non-metastatic tumors were compared with 15 metastatic cases. All of the patients were graded to TNM, Broder俟Q製 and Anneroth俟Q製 system. TNM is clinical assessment and Broder俟Q製 is based on only differentiation of cells. On the other hand, six parameters of Anneroth俟Q製 gives a detail about the morphology of the tumor, invasion criteria in the host tissue and show its correlation with lymph node metastasis. Scoring system of Annearoth俟Q製 grading indicates demarcation points of worseness of tumor and signifies the possibility of lymph node metastasis. Results: Both Anneroth俟Q製(P=0.002) and Broder俟Q製 grading(P=0.012) have been significant but Anneroth俟Q製 one is more significant then Broder俟Q製. Conclusion: Anneroth俟Q製 classification can be taken as a standerd diagnostic factor and predictive factor of lymph node metastasis.


How to cite this article:
Akhter M, Hossain S, Rahman QB, Molla MR. A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis.J Oral Maxillofac Pathol 2011;15:168-176


How to cite this URL:
Akhter M, Hossain S, Rahman QB, Molla MR. A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis. J Oral Maxillofac Pathol [serial online] 2011 [cited 2022 Jan 28 ];15:168-176
Available from: https://www.jomfp.in/article.asp?issn=0973-029X;year=2011;volume=15;issue=2;spage=168;epage=176;aulast=Akhter;type=0