ORIGINAL ARTICLE
Year : 2022 | Volume
: 26 | Issue : 4 | Page : 594-
Alpha-L-fucosidase levels in patients with oral submucous fibrosis and controls: A comparative study
H Suresh1, Nandhini Gunasekaran2, Amritha James2, Rajkumar Krishnan2, Dinesh Kumar Thayalan2, A Ramesh Kumar2
1 Chief Consultant, HM Dental Care, Chennai, Tamil Nadu, India
2 Department of Oral Pathology, SRM Dental College, Chennai, Tamil Nadu, India
Correspondence Address:
Nandhini Gunasekaran
Plot No. 1110, 2nd Main Road, Poombuhar Nagar, Kolathur, Chennai - 600 099, Tamil Nadu
India
Background: Oral submucous fibrosis (OSMF) in recent times has been recognized as a potentially malignant disorder (PMD) with an increased risk of developing oral squamous cell carcinoma with malignant transformation rates that vary from 0.6% to 36%. Alpha-L-fucosidase (AFU) is a lysosomal enzyme that is involved in maintaining the homeostasis of fucose metabolism. In benign and malignant tumors, the cells modulate their surface by increasing fucosylation leading to uncontrolled growth.
Aims and objectives: This study was designed to estimate the levels of salivary and serum AFU in patients with OSMF and healthy controls and also to evaluate the clinical utility of salivary AFU levels over serum.
Materials and Methods: Saliva and blood samples were collected from twenty participants in both the groups (OSMF and healthy controls). Serum and salivary alpha-L-fucosidase levels were measured by enzyme-linked immunosorbent assay. The data were subjected to appropriate statistical analysis.
Results: We found a significant increase in alpha-L-fucosidase level in OSMF compared with healthy subjects. Pearson's correlation showed salivary alpha-L-fucosidase level to have superior sensitivity in detecting OSMF compared with serum alpha-L-fucosidase.
Conclusion: The outcome of this study suggests that salivary alpha-L-fucosidase can be utilized as a biomarker in early detection of oral precancer and cancer.
How to cite this article:
Suresh H, Gunasekaran N, James A, Krishnan R, Thayalan DK, Kumar A R. Alpha-L-fucosidase levels in patients with oral submucous fibrosis and controls: A comparative study.J Oral Maxillofac Pathol 2022;26:594-594
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How to cite this URL:
Suresh H, Gunasekaran N, James A, Krishnan R, Thayalan DK, Kumar A R. Alpha-L-fucosidase levels in patients with oral submucous fibrosis and controls: A comparative study. J Oral Maxillofac Pathol [serial online] 2022 [cited 2023 Mar 29 ];26:594-594
Available from: https://www.jomfp.in/article.asp?issn=0973-029X;year=2022;volume=26;issue=4;spage=594;epage=594;aulast=Suresh;type=0 |
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