ORIGINAL ARTICLE
Year : 2022 | Volume
: 26 | Issue : 4 | Page : 604-
A study on genetic and mutans streptococcal transmissibility of dental caries
Shailja Chatterjee1, Satyawan G Damle2, Nageshwar Iyer3
1 Department of Oral and Maxillofacial Pathology, Yamuna Institute of Dental Sciences and Research, Yamuna Nagar, Haryana, India
2 Former Vice-chancellor, M. M. (Deemed to be) University, Mullana, Ambala, Haryana, India
3 Former Principal, MM College of Dental Sciences and Research, M. M. (Deemed to be) University, Mullana, Ambala, Haryana, India
Correspondence Address:
Shailja Chatterjee
Oral Cancer Screening and Diagnostic Centre, 3/1323, Chatterjee Cottage, Janak Nagar, Saharanpur, Uttar Pradesh - 247 001
India
Background: Dental caries is characterized by an interplay between environmental and genetic factors.
Aim: The aim of this study was to analyse the transmissibilities of high caries risk chromosomal loci at 5q 12.1-13.3 and low caries risk chromosomal loci at 13q31.1 and Streptococcus mutans (S. mutans) in family units.
Materials: This prospective cohort study was performed on 56 families grouped into four: (a) Group I: 18 families of children with caries affected primary teeth; (b) Group II: 21 families of children with caries in permanent teeth; (c) Group III: 6 families of children with no caries in primary teeth and (d) Group IV: 12 families of children with no caries in permanent teeth. Blood, saliva and plaque samples were collected from consenting study participants. Isolated DNAs were subjected to polymerase chain reactions using suitable primers. Data collected was analysed with ANOVA and Chi-squared test.
Results: Wide expression of chromosome loci 5q12.1-13.3 was obtained in both blood and saliva samples. For chromosome loci 13q31.1, no expression was found in saliva samples, hence indicating its local absence. For the GtfB expression, transmissibility was common for a single band expressing S. mutans.
Conclusion: This study reflects upon newer findings in the field of genetic research on dental caries.
How to cite this article:
Chatterjee S, Damle SG, Iyer N. A study on genetic and mutans streptococcal transmissibility of dental caries.J Oral Maxillofac Pathol 2022;26:604-604
|
How to cite this URL:
Chatterjee S, Damle SG, Iyer N. A study on genetic and mutans streptococcal transmissibility of dental caries. J Oral Maxillofac Pathol [serial online] 2022 [cited 2023 Mar 29 ];26:604-604
Available from: https://www.jomfp.in/article.asp?issn=0973-029X;year=2022;volume=26;issue=4;spage=604;epage=604;aulast=Chatterjee;type=0 |
|
|
|
